Figure 12

Cell migration under different environmental conditions. Mechanical, flow and chemical inputs are activated/deactivated in different combinations and gradient directions. Case A: only the mechanical input is activated, applying a linear stiffness gradient (same as case 1 in previous section) on the x-direction. Case B: flow acts in x-direction. Case C: flow and a chemical gradient are both applied in x-direction. Case D: flow is applied in x-direction and a stiffness gradient in y-direction. Case E: flow and a chemical gradient are applied in x-direction and a stiffness gradient in y-direction. Green box represents the gel and coloured arrows the gradient directions. Migration directionality was determined as the angle of each turn in the track relative to the x-direction. Coloured numbers represent the count of turns at each simulation.