Figure 8

Migration trajectories and computed speeds. A) 3D and x-y projected trajectories for: case 1 - linear stiffness gradient, case 2 - exponential stiffness gradient. Initial position is the same for both cases. Light blue circle and orange triangle show the final location of the cell centroid for cases 1 and 2 respectively. B) Cell migration speeds at different times of simulation. Legend in A is used to represent the cases in the x-axis of B. Mean speed is calculated as the average cell speed at each step, whereas the effective speed takes into account only the initial and final cell location at a certain time.