Fig. 4
From: Computational modeling of bone fracture non-unions: four clinically relevant case studies
In silico and in vivo results of the effects of MSC transplantation on atrophic non-union formation. Ai In silico results for the treatment with the cell transplant injected in the center of the callus. Aii A comparison of experimentally measured (Exp) and numerically calculated (Sim) tissue constituents present within the interfragmentary gap of control (carrier solution injected) and treatment (MSC transplant) groups (o*p < 0.005, students t test). Simulation results are shown for a central injection of the carrier solution. Bi In silico results for the treatment with the cell transplant injected excentrally in the callus. Bii A comparison of experimentally measured (Exp) and numerically calculated (Sim) tissue constituents present within the interfragmentary gap of control (carrier solution injected) and treatment (MSC transplant) groups (o*p < 0.005, students t-test). Simulation results are shown for an excentral injection of the carrier solution. C Simulation results for the treatment with the cell transplant injected outside the callus. PFW post fracture week. (adapted from Geris et al. [48], licensed under CC BY 4.0)