Fig. 10From: Modeling migration in cell colonies in two and three dimensional substrates with varying stiffnesses3D Simulation runs of cells within different E c and identical E s . In a upper half (red) of E s  = 0.5 kPa, lower half (blue) is E s  = 10 kPa. E c  = 0.5 kPa. In b upper half (red) E s  = 3 kPa, lower half (blue) E s  = 7 kPa. And E c  = 1 kPa. Both simulations depict how the E s value primarily affects the velocity and spread of the cells over time, whereas the choice of E c can have a greater effect on cell migrationBack to article page