In silico cell and tissue science
© Geris and Vermolen; licensee Springer. 2014
Received: 12 May 2014
Accepted: 12 May 2014
Published: 23 October 2014
The expression “in silico” studies is used to denote these studies that are performed on a computer or via computer simulation. The phrase was coined in 1989 as an analogy to the Latin phrases in vivo, in vitro, and in situ, which are commonly used in biology, and which refer to experiments done in living organisms, outside of living organisms, and where they are found in nature, respectively .
Research in the natural sciences, such as biology and medicine (henceforth jointly termed biomedicine), develops through the formulation of hypotheses, which are to be validated by reproducible experiments. The validation of theoretical concepts can only take place once the biological hypotheses have been quantified in terms of mathematically sound relations. The mathematical relations are often formulated in concepts like (partial) differential equations, geometrical relations or stochastic processes, to mention a few of them. In order to simulate the biological processes of interest on the basis of the model concepts, rigorous mathematical techniques should be used or developed. Compared to the intimate cooperation between mathematics and (computational) physics, the field of mathematical and in silico biomedicine is rather new.
The goal of the journal ‘In silico cell and tissue science’ is to promote basic and applied in silico research, at both cellular and tissue level, that integrates the expanding knowledge in the fields of biology, mathematics, engineering and their interplay. In particular, contributions are appreciated that
quantify the physical, biological and chemical environment in which cells and tissues behave and function in healthy conditions and pathological conditions;
describe and quantify cellular and tissue responses under different environmental conditions and stimulations either from mechanical, chemical or other biophysical origins;
determine and scrutinize relations between chemical, physical, mechanical and biological processes such as cell growth, division, differentiation, death, migration and tissue growth, remodeling, repair or decay.
Contributions on the nano, micro, and/or macrolevels are welcome. Especially encouraged are analytical and computational models based on physico-biological principles as well as topics on new mathematical methods that facilitate building, analysis, optimization and validation of models of biological systems in both cell and tissue scales. Approaches are predominantly silico based, but can also involve experimental contributions assessing the foundations of cellular and tissue phenomena. Additionally, in silico tools and technologies allowing for the interpretation and exploitation of experimental data (such as the development of virtual histopathology by image analysis) belong to the scope of this journal.
We hope that the creation of the journal of ‘In silico cell and Tissue Science’ can play a role in the further development and exploitation of the fields of in silico biology and in silico medicine.
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